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Macrophage-1 antigen

Macrophage-1 antigen is a complement receptor consisting of CD11b and CD18. The integrin α chain is noncovalently bound to the integrin β chain. It binds to iC3b and can be involved in cellular adhesion, binding to the intercellular adhesion mole ...

YWTD repeat

YWTD repeats are four-stranded beta-propeller repeats found in low-density lipoprotein receptors. The six YWTD repeats together fold into a six-bladed beta-propeller. Each blade of the propeller consists of four antiparallel beta-strands; the inn ...

Toll-like receptor 11

Toll-like receptor 11 is a protein that in mice and rats is encoded by the gene TLR11, whereas in humans it is represented by a pseudogene. TLR11 belongs to the toll-like receptor family and the interleukin-1 receptor/toll-like receptor superfami ...

Activin receptor

An Activin receptor is a receptor which binds activin. Types include: Activin type 2 receptors Activin type 1 receptors These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic ...

Secretory Pathway Ca²⁺ ATPase

SPCA is found primarily in the membranes of the golgi apparatus in increasing concentrations from the cis- to the trans-golgi compartments. Following a calcium spike, SPCA proteins are responsible for transporting Ca 2+ ions from the cytosol to t ...

Fat embolism syndrome

Fat embolism syndrome occurs when fat enters the blood stream and results in symptoms. Symptoms generally begin within a day. This may include a petechial rash, decreased level of consciousness, and shortness of breath. Other symptoms may include ...

TraumaMan

TraumaMan is a surgical simulation manikin used for teaching surgical skills, including the American College of Surgeons Advanced Trauma Life Support program, to medical professionals. TraumaMan is also used to advance surgical skills in combat s ...

Methylammonium lead halide

Methylammonium lead halides are solid compounds with perovskite structure and a chemical formula of CH 3 NH 3 PbX 3, where X = I, Br or Cl. They have potential applications in solar cells, lasers, light-emitting diodes, photodetectors, radiation ...

Ruddlesden-Popper phase

Ruddlesden-Popper phases are type of perovskite structure that consists of two-dimensional perovskite-like slabs interleaved with cations. The general formula of RP phase is A n+1 B n X 3n+1, where A and B are cations, X is an anion, and n is the ...

Potassium channel blocker

Dalfampridine, A potassium channel blocker has also been approved for use in the treatment of multiple sclerosis.

E-4031

E-4031 acts on a specific class of voltage-gated potassium channels mainly found in the heart, the hERG channels. hERG channels Kv11.1 mediate the I Kr current, which repolarizes the myocardial cells. The hERG channel is encoded by ether-a-go-go ...

HMR 1883

HMR 1883 ethyl"-2-methoxyphenyl"sulfonyl-3 methylthiourea) and its sodium salt HMR 1098, are experimental anti-arrhythmic drugs classified as sulfonylthiourea compounds. Their main purpose is to treat ventricular fibrillation caused by myocardial ...

Sodium channel blocker

The following naturally-produced substances block sodium channels by binding to and occluding the extracellular pore opening of the channel: Neosaxitoxin NSTX Alkaloids Saxitoxin STX Tetrodotoxin TTX

MRI contrast agent

MRI contrast agents are contrast agents used to improve the visibility of internal body structures in magnetic resonance imaging. The most commonly used compounds for contrast enhancement are gadolinium-based. Such MRI contrast agents shorten the ...

Calsyntenin

Calsyntenins are type I transmembrane proteins that belong to the cadherin superfamily. Their name comes from their ability to bind calcium. In birds and mammals, they consist of three family members, in nematodes one ortholog is known. Cst1 CLST ...

C2C12

C2C12 is an immortalized mouse myoblast cell line. The C2C12 cell line is a subclone of myoblasts that were originally obtained by Yaffe and Saxel at the Weizmann Institute of Science in Israel in 1977. Developed for in vitro studies of myoblasts ...

Myosatellite cell

Myosatellite cells, also known as satellite cells or muscle stem cells, are small multipotent cells with very little cytoplasm found in mature muscle. Satellite cells are precursors to skeletal muscle cells, able to give rise to satellite cells o ...

Anaphase

Anaphase, is the stage of mitosis after the process of metaphase, when replicated chromosomes are split and the newly-copied chromosomes are moved to opposite poles of the cell. Chromosomes also reach their overall maximum condensation in late an ...

Cdc14

Cdc14 and Cdc14 are a gene and its protein product respectively. Cdc14 is found in most of the eukaryotes. Cdc14 was defined by Hartwell in his famous screen for loci that control the cell cycle of Saccharomyces cerevisiae. Cdc14 was later shown ...

Mitotic exit

Mitotic Exit is an important transition point that signifies the end of mitosis and the onset of new G1 phase for a cell, and the cell needs to rely on specific control mechanisms to ensure that once it exits mitosis, it never returns to mitosis ...

Pom1

Pom1 is a polarity protein kinase in fission yeast, Schizosaccharomyces pombe, that localizes to cell ends and regulates cell division. As the cell lengthens, the level of Pom1 in the middle declines, which triggers mitosis. The gene pom1 codes f ...

Prometaphase

Prometaphase is the phase of mitosis following prophase and preceding metaphase, in eukaryotic somatic cells. In prometaphase, the nuclear membrane breaks apart into numerous "membrane vesicles", and the chromosomes inside form protein structures ...

Collagen VI

Collagen VI is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle function and stabilizes the cell membrane. It is synthesized by a complex, multistep pathway that leads ...

Type XXVII collagen

Type XXVII collagen is the protein predicted to be encoded by COL27A1. It was first described by Dr. James M. Pace and his colleagues at the University of Washington. It is related to the fibrillar collagens: type II, type XI, and type XXIV. Curr ...

Laminin

Laminins are high-molecular weight proteins of the extracellular matrix. They are a major component of the basal lamina, a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the bas ...

Hypochondrogenesis

Hypochondrogenesis is a severe genetic disorder causing malformations of bone growth. The condition is characterized by a short body and limbs and abnormal bone formation in the spine and pelvis. Hypochondrogenesis is a subtype of collagenopathy, ...

Bucculatrix thurberiella

Bucculatrix thurberiella, the cotton leaf perforator, is a moth of the family Bucculatricidae. It was first described by August Busck in 1914. It is native to the south-western United States and northern Mexico. It is an introduced species in Haw ...

Dorudontinae

Subfamily Dorudontinae Genus Ancalecetus Ancalecetus simonsi Genus Chrysocetus Chrysocetus fouadassii Chrysocetus healyorum Cynthiacetus maxwelli Cynthiacetus peruvianus Genus Cynthiacetus Dorudon serratus Dorudon atrox Genus Dorudon Masracetus m ...

HLA-B15

HLA-B15 is an HLA-B serotype. The serotype identifies the B*15 gene-allele protein products of HLA-B. B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, ...

HLA-B17

HLA-B17 is an HLA - B serotype. B17 is a broad antigen serotype that recognizes the B57 and B58 split antigen serotypes. B17 is still encountered in the current literature, although most studies now use B57/B58 or gene typing designators. Both se ...

HLA-B57

HLA-B57 is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype B58. The serotype identifies the more common HLA-B*58 gene products. Like B58, B57 is involved in drug-induced inflammatory skin disorders.

HLA-B58

HLA-B58 is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B*58 gene products. B*5801 is associated with allopurinol induced inflammatory necrotic skin dis ...

HLA-B75

HLA-B75 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. B75 is one of many split antigens of the broad antigen, B15. B75 B*1502 is associated with a severe drug-induced skin condition in ethnic Ea ...

Gene cluster

A gene family is a set of homologous genes within one organism. A gene cluster is a group of two or more genes found within an organisms DNA that encode for similar polypeptides, or proteins, which collectively share a generalized function and ar ...

Metabolic gene cluster

Metabolic gene clusters or biosynthetic gene clusters are tightly linked sets of mostly non-homologous genes participating in a common, discrete metabolic pathway. The genes are in physical vicinity to each other on the genome, and their expressi ...

MIR34A

microRNAs miRNAs are short 20-24 nt non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymer ...

MIR561

microRNAs miRNAs are short 20-24 nt non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymer ...

Histone H2A.Z

Histone H2A.Z is a protein that in humans is encoded by the H2AFZ gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of D ...

Encyclopedic dictionary

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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